Create a Cell-style SCI graphical abstract: ALDH3A2 regulates monocyte ferroptosis in sepsis. Pastel vector style, clean arrows, Times New Roman. Left: “ALDH3A2 downregulated in sepsis”: bacterial Sepsis → PPARγ↓ → ALDH3A2 promoter activity↓ → ALDH3A2 mRNA↓ → ALDH3A2 protein↓. Upper right: “Healthy Monocyte (Ferroptosis Inhibited)”: ALDH3A2↑ → KEAP1↓ → NRF2↑ → GPX4 transcription↑ → GPX4 protein↑ → Fe²⁺↓/Lipid ROS↓ → Ferroptosis blocked, phagocytosis↑, normal PD-1/PD-L1. Lower right: “Damaged Monocyte (Ferroptosis Promoted)”: ALDH3A2↓ → KEAP1↑ → NRF2↓ → GPX4 transcription↓ → GPX4 protein↓ → Fe²⁺↑/Lipid ROS↑ → Ferroptosis promoted, phagocytosis↓, increased PD-1/PD-L1.

The image shows a poster with text and an image of a virus, illustrating the effects of alhd3a2 downregulated in sepsis. The text on the poster explains the potential risks associated with the virus, such as increased risk of infection, increased immunity, and increased immunity. The virus is depicted in a bright yellow color, with its antennae and legs clearly visible.